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Abstract:

Despite the comparatively low morbidity rate, skin melanoma is known for its high mortality rate. High metastatic potential of the tumor, urges the necessity of improving methods of diagnostics, which can identify metastasis and assess the degree of dissemination at the early stage of disease.

We have analyzed results of ultrasound imaging of one of the earliest and frequent types of progression of melanoma - metastasis in regional lymphatic nodes. The article presents results of examination of 182 patients with skin melanoma with early metastasis in lymphatic nodes, also - characteristics of the image of tumor changes are described.

The high informativeness of ultrasound research for timely identification of metastatic changes and, respectively, the increase of the rate of survival of patients with skin melanoma are demonstrated.

 

References

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2.     Balch C.M., Gershenwald J.E., Soong S.J., Thompson J.F., Atkins M.B., Byrd D.R., et al. Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol. 2009; 27(36): 6199-6206.

3.     College of American Pathologists (CAP). Protocol for the Examination of Specimens from Patients with Melanoma of the Skin [Электронный ресурс]//Version 3.2.0.0. June 2011. URL: http://www.cap.org/apps/ docs/committees/cancer/cancer_protocols/2012/ SkinMelanoma_12protocol.pdf (дата обращения: 2012.12.21)

4.     Thompson J.F, Shaw H.M. Sentinel node mapping for melanoma: results of trials and current applications. Surg. Oncol Clin. N. Am. 2007;16(1): 35-54.

5.     Ferrone C.R., Panageas K.S., Busam K. et al. Multivariate prognostic model for patients with thick cutaneous melanoma: importance of sentinel lymph node status. Ann. Surg. Oncol. 2002; 9(7): 637-645.

6.     Gershenwald J.E., Mansfield P.F., Lee J.E. et al. Role for lymphatic mapping and sentinel lymph node biopsy in patients with thick (> or = 4 mm) primary melanoma. Ann. Surg. Oncol. 2000; 7(2): 160-165.

7.     O’Brien CJ., Uren R.F, Thompson J.F. et al. Prediction of potential metastatic sites in cutaneous head and neck melanoma using lymphoscintigraphy. Am. J. Surg. 1995; 170(5): 461-466.

8.     Uren R.F. Lymphatic drainage of the skin. Ann. Surg. Oncol. 2004; 11(3 Suppl): 179-185.

9.     Blum A., Schlagenhauff B., Stroebel W. et al. Ultrasound examination of regional lymph nodes significantly improves early detection of locoregional metastases during the follow-up of patients with cutaneous melanoma. Cancer. 2000; 88 (11): 2534-2539.

10.   Voit C.A., Van Akkooi A.C.J., Sc^fer-Hesterberg G. et al. Ultrasound Morphology Criteria Predict Metastatic Disease of the Sentinel Nodes in Patients With Melanoma. J. Clin. Oncology. 2010; 28 (5): 847-852.

11.   Voit C.A., van Akkooi A.C.J., Schaefer-Hesterberg G. et al. Rotterdam criteria for sentinel node (SN) tumor burden and the accuracy of ultrasound (US)-guided fine-needle aspiration (FNAC) cytology: Can US-guided FNAC replace SN staging in patients with melanoma? J. Clin. Oncol. 2009; 27: 4994-5000.

12.   Струков А.И., Серов В.В. Патологическая анатомия. 4-е изд. М.: Медицина, 1995. 688. 

 

 

Abstract:

Mediastinal lymphadenopathy is well diagnosed with diagnostic beam methods in primary care outpatient care. The problem is the heterogeneity of this group of diseases, requiring differential diagnosis, on the basis of which individual treatment plan is developed. Morphological verification is a prerequisite for the effective management of such patients

Aim: was to improve the diagnosis of patients with different mediastinal lymph node using endobronchial ultrasonography (EBUS) by evaluation of EBUS cabinet, algorithmization and improvement of its structure and working procedure.

Materials and methods: for the period 2012-2016, 115 patients underwent endobronchial ultrasonography, in 71 cases of which (45,8%) EBUS was accompanied by fine-needle aspiration biopsy (FNAB).

Results: we had investigated the capacity, efficiency Further development of and prospects were identified.

Conclusions: optimizing of structure of the EBUS cabinet, algorithmization of procedure can improve the level of the differential diagnosis in patients with mediastinal lymph node lesion anc reduce the time of examination of patients in this group.

 

References

1.     Chissov V.I., Dar'jalova S.L. Onkologija. [Oncology]. M.: «GJeOTAR-Media» 2007:560S. [In Russ].

2.     Davydov M. I., Machaladze Z. O., Polockij B. E. Et al. Mezenhimal'nye opuholi sredostenija (obzor literatury). [Mesenchymal tumors of the mediastinum (review)]. Sibirskij onkologicheskij zhurnal. 2008; 1:64-74 [In Russ].

3.     Nechipaj A. M., Orlov S. Ju., Fjodorov E. D. JeUS-buka. [EUS-book]. M.: Practicheskaya meditcina. 2013;243-245 [In Russ].

4.     Koroljov V. N., Burdjukov M. S., Surovcev I. Ju., Sazhina E. A. Jendobronhial'naja ul'trasonografija sredostenija i bronho-ljogochnoj sistemy. [Endobronchial ultrasonography of mediastinal and bronchial-pulmonary system]. Povolzhskij onkologicheskij vestnik. 2016;2:14-25 [In Russ].

5.     Prilozhenie k prikazu MZSr ot 27.12.2011 N1664n «Ob utverzhdenii nomenklatury medicinskih uslug» URL.: https://www.rosminzdrav.ru/documents/6975-prikaz-minzdravsotsrazvitiya-rossii-1664n-ot-27-dekabrya-2011-g (Data obrashhenija 23.10.2014) [In Russ].

6.     Prikaz Ministerstva zdravoohranenija RF ot 15 nojabrja  2012 g. N 915n «Ob utverzhdenii Porjadka okazanija medicinskoj pomoshhi naseleniju po profilju «onkologija» URL.: http://www.gov.cap.ru/UserFiles/orgs/ Grvid_11/oncologiya.pdf (Data obrashhenija 23.10.2014) [In Russ].

7.     Prikaz Ministerstva zdravoohranenija i medicinskoj promyshlennosti ot 31 maja 1996 g . №222 «O sovershenstvovanii sluzhby jendoskopii v uchrezhdenijah zdravoohranenija Rossijskoj Federacii» URL.: http://www.endoscopy.ru/doctor/222.html (Data obrashhenija 23.10.2016) [In Russ].

8.     Sanitarno-jepidemiologicheskie pravila SP 3.1.2659-10 «Izmenenija i dopolnenija N 1 k sanitarno-jepidemiologicheskim pravilam SP 3.1.1275-03 «Profilaktika infekcionnyh zabolevanij pri jendoskopicheskih manipuljacijah» URL.: http://pravo.gov.ru/proxy/ips/?docbody=&nd=102141277 &rdk=&backlink=1 (Data obrashhenija 10.10.2016) [In Russ].

9.     Podol'skij V. V., Podol'skaja E. A., Kiseljov I. L. Intervencionnaja jendobronhoul'trasonografija v diagnostike peribronhial'nogo raka ljogkogo. [Interventional endobronchial ultrasonography in the diagnosis of peribronchial cancer of lung]. VIII nauchno-prakticheskaja konferencija intervencionnyh onkoradiologov. [VIII scientific conference of interventional onkoradiology] M., 2015; S. 40-41 [In Russ].

 

 

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